Feature-Variant Pairs

Feature-Variant pairs are a basic unit in CIViC, which consist of a Feature and Variant, which associate naturally, such as BRAF V600E, or BCR::ABL1 Fusion. When Feature-Variant pairs are shown in the CIViC user interface, each entity is clickable, and will bring the user to the respective Feature or Variant which was clicked. The Variant in a Feature-Variant pair is associated exclusively to the given Feature, but the Feature may be associated to more than one Variant. In fact, there are no limitations on how many Variants a Feature can have. For instance, a gene like BRAF might can have dozens or hundreds of Variants associated to it. Examples of Feature-Variant pairs in CIViC are shown below.

Feature Variant Pairs in CIViC

Figure 1: Examples of Feature-Variant pairs in CIViC. Features may be Genes, Factors, or Fusions, and each Variant is specifically asociated to a single Feature, making up the Feature-Variant pair.