Curating GenesΒΆ

The CIViC Gene knowledge model provides summarized gene-level context for all CIViC variants contained by the gene.

For a gene record to become visible, it must be associated with at least one Evidence Item that describes a variant contained by the gene.

Genes are identified within CIViC using Entrez Gene names and IDs. Once a gene record exists it is automatically linked (via Entrez Gene) to additional gene-level details using the mygene.info resource and to the Drug Gene Interaction Database.

Finally, a high-level summary of the clinical relevance of the gene (as described by curated evidence/variants) can be curated along with supporting references (e.g., relevant reviews). Additional instruction on curating individual components of genes are provided in the Knowledge Model docs for Genes docs.