Direction

Evidence Direction indicates if the Evidence Statement supports or refutes the clinical significance of an event.

Understanding Evidence Direction

The available options include: “Supports” or “Does not support”. Nuanced examples for how to correctly use the Evidence Direction for Predictive Evidence Types are shown in the section on curating Evidence Items. Note that Predisposing and Oncogenic Evidence do not have an Evidence Direction or Clinical Significance. These should be established at the assertion level using the appropriate guidelines. This is also discussed in the section on curating Evidence Items in the link above.

Curating Evidence Direction

Evidence Direction interpretation differs slightly depending on the Evidence Type.

Direction for Predictive Evidence

Direction

Symbol

Definition

Supports

The experiment or study supports this variant’s response to a drug

Does not support

The experiment or study does not support, or was inconclusive of an interaction between the variant and a drug

Direction for Diagnostic Evidence

Direction

Symbol

Definition

Supports

The experiment or study supports variant’s impact on the diagnosis of disease or subtype

Does not support

The experiment or study does not support the variant’s impact on diagnosis of disease or subtype

Direction for Prognostic Evidence

Direction

Symbol

Definition

Supports

The experiment or study supports a variant’s impact on prognostic outcome

Does not support

The experiment or study does not support a prognostic association between variant and outcome

Direction for Predisposing Evidence

Direction

Symbol

Definition

N/A

Directionality is only applied at the assertion level

Direction for Oncogenic Evidence

Direction

Symbol

Definition

N/A

Directionality is only applied at the assertion level

Direction for Functional Evidence

Direction

Symbol

Definition

Supports

The experiment or study supports this variant causing alteration or non-alteration of the gene product function

Does not support

The experiment or study does not support this variant causing alteration or non-alteration of the gene product function