Evidence Overview

The following figure shows the attributes of a CIViC Evidence Item, and the options or values available for each.

The rows in the following table describe the minimal components of a CIViC Evidence Item. Several Evidence Statements are synthesized at the Variant level into Variant Summaries but each Evidence Statement is directly linked to a single article in PubMed. More specific guidelines about Evidence Item components can be found in additional help tabs.

Evidence Attributes

Attribute

Description

Example

Source

Gene

The symbol and ID of the gene implicated.

ESR1 (Entrez ID: 2099)

CIViC (Entrez)

Variant

Genomic event/mutation (Single nucleotide variant, Insertion/deletion, Gene fusion, Copy number variant, etc.) implicated.

Y537S

CIViC

Statement

Human readable interpretation. Free-form text summary of this event’s potential clinical interpretations. This interpretation is the synthesis of all other information about an event and its relevance to clinical action and should be the living product of active discussion.

This study of 178 non-small cell lung cancer patients, the appearance of T790M mutation lead to resistance to gefitinib.

CIViC

Level

The type of experiment from which the evidence is curated. From inferential, to proven association in clinical medicine. Refer to the additional documentation on evidence levels for definitions of the five levels allowed in CIViC: validated, clinical, pre-clinical, case study, and inferential.

Level B - Clinical Evidence.

CIViC

Type

Category of clinical action/relevance implicated by event. Refer to the additional documentation on evidence types for details on how to enter evidence of each of the four types: Predictive, Prognostic, Predisposing and Diagnostic. See ‘Evidence Type’ tab for more information.

Predictive - The variant is predictive of sensitivity or resistance to a therapeutic.

CIViC

Direction

An indicator of whether the evidence statement supports or refutes the clinical significance of an event. See ‘Evidence Type’ tab for more information.

Supports - the evidence supports the clinical significance.

CIViC

Clinical Significance

The association with diagnostic/prognostic end point or treatment. See ‘Evidence Type’ tab for more information.

Resistant or Non-response - mutation is associated with resistance to therapy.

CIViC

Origin

Presumed cellular origin of the Variant in samples from the literature citation where the clinical effect of this Variant is being evaluated.

Somatic

CIViC

Disease

Specific disease or disease subtype that is associated with this event and its clinical implication. Links directly to Disease Ontology.

Estrogen-receptor positive breast cancer (DOID: 0060075).

CIViC (Disease Ontology)

Associated Phenotype

Drug

For predictive evidence, indicates the therapy for which sensitivity or resistance is indicated (With NCIt ID if available).

Tamoxifen, Raloxifene (NCIt IDs: C62078, C62078).

CIViC (NCIt)

Drug Interaction Type

For predictive evidence involving more than one drug, specifies the relationship between these drugs by indicating whether the drugs are Subtitutes for each other or are used in Sequential or Combination treatments.

Substitutes - The drugs listed are often considered to be of the same family, or behave similarly in a treatment setting.

CIViC

Citation

Publication where the event was described/explored automatically generated from curator-provided PubMed ID and links to internal CIViC publication page showing all Evidence Items from the publication.

Toy et al., 2013, Nat. Genet. (PMID: 24185512)

CIViC (PubMed)

PubMed ID

PubMed ID for publication where the event was described/explored with direct link to PubMed.

24185512

CIViC (PubMed)

Clinical Trial

Evidence Rating

A rating on a 5-star scale, portraying the curators trust in the experiments from which the evidence is curated. Refer to the additional documentation on trust ratings for guidance on how to score an evidence item.

5-stars - Strong, well supported evidence from a lab or journal with respected academic standing. Experiments are well controlled, and results are clean and reproducible across multiple replicates.

CIViC