Introduction to CIViC

The Clinical Interpretation of Variants in Cancer (CIViC) knowledgebase is a free and open resource for public use, available online at To get started using and contributing to CIViC, we recommend that you review the Video Tutorials. These videos cover CIViC and its goals; finding documentation and help resources; browsing and searching knowledgebase contents; adding new evidence, variant summaries, coordinates, gene summaries, and assertions to CIViC; and editing existing CIViC content.

For a primer on the fundamentals of cancer variant interpretation, we highly recommend that new users start by reading the CIViC paper and these recently published Standards and Guidelines proposals:

The CIViC Ecosystem of Collaborators, Moderators, and Other Stakeholders

The CIViC project aims to facilitate a collaborative ecosystem of research scientists, clinical scientists, and patient advocates dedicated to curating an accurate and relevant database of clinical interpretations of cancer variants. The diagram below shows how the various stakeholders in the CIViC ecosystem collaborate to curate and utilize the database.